But shpa at 6 weeks pregnant. Is it possible for pregnant women to drink the drug "No-Shpa", for which it is prescribed in the early and late stages? Contraindications for use

"No-shpa" is medicinal product, which is produced in Hungary, which makes it accessible to many social strata of the population.

The remedy is very popular among women - "No-shpa" effectively relieves muscle spasm, helping to relieve pain during menstruation.

In addition, the tablets quickly help to eliminate headaches, toothaches, as well as pain in the bones and joints.

Very often, "No-shpa" is used to treat pregnant women with a diagnosis of "". The use of the drug in this case is fully justified, since this pathology can lead to spontaneous abortion. Pregnant women should carefully study the instructions before using the medicine and obtain a doctor's opinion on the state of health, as the drug has contraindications and can cause negative consequences if used incorrectly.

The active ingredient of the drug is drotaverine (1 tablet contains 40 mg of this substance), which has a pronounced antispasmodic effect on smooth muscles. The maximum effectiveness is noted in relation to the organs of the genitourinary system, the gastrointestinal tract, as well as the bile ducts.

The active substance of the drug is actively absorbed, quickly distributed over organs and tissues. The maximum concentration of drotaverine is reached 45-60 minutes after taking the medication.

For this reason, "No-shpa" is the drug of choice (that is, the one that is prescribed in the first place) when an increased tone occurs in pregnant women.

The drug is available in three dosage forms: tablets, injection and suppositories.

Application of No-shpa

Conducted studies, as well as many years of experience of Russian and foreign doctors, indicate that the use of "No-shpa" during pregnancy did not adversely affect the developing fetus, so the manufacturer does not declare pregnancy as a contraindication for therapy with this drug.

However, it is worth considering the fact that this antispasmodic has a relaxing effect on all smooth muscles, including the cervix. Therefore, taking "No-shpy" in the third trimester is not recommended because of the danger.

On early dates treatment with "No-shpoy" does not cause consequences, while it effectively relieves spasm and tension of the uterus and helps to maintain pregnancy.

Drotaverine in very small quantities can penetrate the placental barrier, so you should avoid uncontrolled use of the drug (especially in the first three months of pregnancy).

Indications during early and late pregnancy

• Tone of the uterus.

The main indication for the appointment of this medication is uterine hypertonicity. In this condition, a woman feels a strong tension in the abdomen, the uterus turns to stone, and may appear.

All these symptoms are an indication for the immediate initiation of drug therapy aimed at removing muscle tone and reduction of pain.

• Pain syndrome.

In the 2nd and 3rd trimester, "No-shpa" can be used for headaches, toothaches, and also for periodic pain in the abdomen. Other types of pain syndrome can also be stopped with this medication (treatment in this case is carried out until the symptoms are completely eliminated). In the first trimester "No-shpa" can be applied.

• Preparation of the cervix for childbirth.

On later dates, if a woman is expecting the birth of a baby in the hospital, she may be assigned "No-shpu" as an auxiliary component before childbirth. The drug will help relax the cervix and prepare it for disclosure, as well as relieve pain and avoid perineal tears.

Most often, expectant mothers are prescribed the drug in the form of tablets for oral administration and suppositories.

If a woman suffers from intolerance to milk sugar (lactose), the choice is made in favor of an injection solution that does not contain this substance.

Injections are also shown in a serious condition of a pregnant woman, since with intravenous and intramuscular administration, the effect occurs almost instantly.

How to take No-shpu? Medication dosage

If the drug is administered as an injection, then it should be borne in mind that the recommended daily dosage is from 40 to 240 mg (depending on the severity of the pathology and concomitant symptoms).

To obtain an instant result, the drug should be administered intravenously, since the active substance will immediately enter the bloodstream.

The drug treatment regimen is very individual and depends on many factors, including the severity of the diagnosis, the presence of complications, the health of the pregnant woman, and many others.

For each patient, the dosage is selected taking into account the listed factors.

Standard schemas look like this:

• with the threat of abortion - 2 tablets 3 times a day;
• with uterine tone - 1-2 tablets 3 times a day;
• to relieve pain (toothache, pain in the abdomen, etc.) - 1 tablet 3 times a day (until the symptom is eliminated);
• during fights at the beginning labor activity- 2 tablets once.

The daily dosage of "No-shpy" should not exceed 6 tablets!

The duration of treatment is usually from 3 to 5 days, but can be increased according to the appointments of the supervising specialist.

Possible side effects

During treatment with the drug, adverse reactions may occur, which usually disappear after discontinuation of the drug. These include:

• heart rhythm disturbances;
• migraine;
• digestive disorders (,);
• urticaria, rash, itching;
• angioedema (very rare).

The appearance of any of these symptoms during pregnancy requires stopping the medication and contacting a healthcare professional.

Contraindications

Not all pregnant women can use this medicine, as there are contraindications for its use.

Among them:

• violations (in severe form) in the work of the liver and kidneys;
• severe heart disease;
• arterial hypotension;
• lactose intolerance (for tablets).

A relative contraindication for the use of "No-shpa" is the second and third trimester - the use of the drug during this period is allowed only if absolutely necessary and subject to constant monitoring of the woman's condition in a hospital.

What can replace No-shpu during pregnancy?

If for some reason therapy with this drug is not possible, the woman is prescribed analogues of "No-shpy" containing drotaverine and having identical pharmacological properties. These include:

• "Drotaverine";
• "Droverin";
• "Spazmol";
• "Bioshpa";
• "Spasmonet";
• "Vero-Drotaverin";
• "Nosh-Bra".

Replacement medicinal product without consulting a doctor during pregnancy is not allowed!

"No-shpa" is an effective medicine for relieving muscle spasms and eliminating pain. The drug does not have a toxic effect on the fetus, therefore it is widely used in medical practice for the treatment of pregnant women.

In the absence of contraindications, "No-shpa" can be safely used in the first trimester as part of therapy aimed at maintaining pregnancy. Further use of the drug (starting from the second trimester) should be carried out only in stationary conditions.

Taking any drugs during pregnancy is not recommended, but sometimes you can not do without medication. In such cases, doctors can prescribe medications to the woman that have the least adverse effect on the fetus. Among these drugs is "No-shpa". However, can we be sure that the use of "No-shpa" during pregnancy in the 3rd trimester will not harm the baby? Let's figure it out.

In what cases is "No-shpu" used?

Everyone knows that No-shpa has been used for headaches during pregnancy for a long time. However, is it really that effective? In what conditions is this drug generally used?

The active substance of the drug is drotaverine. It is sold in pure form. Its function is to relieve muscle spasm, reduce the tone of smooth muscles, reduce their motor activity and have a dilating effect on blood vessels.

"No-shpa" from a headache during pregnancy is actively recommended by doctors. However, not everyone is of the opinion that it is safe for the mother and fetus. There is evidence that after taking the drug, toxicosis increases, appetite worsens, weakness increases and heart rate increases. Experts conclude that it is necessary to be very careful when taking this remedy.

Action "No-shpy"

The use of "No-shpy" during pregnancy in the 3rd trimester may be due to the need to reduce the excitability of the uterus. In addition, the drug is used to relieve cervical spasm during childbirth.

The effect of the drug on the body of a pregnant woman is as follows:

• decrease in uterine tone;
• decrease in the contractile activity of the smooth muscles of the uterus;
• normalization of blood supply to organs.

However, the use of "No-shpy" during pregnancy is not limited to gynecological indications. Very often, it is prescribed to relieve pain in chronic diseases of the gastrointestinal tract in the acute stage, as well as in violation of the bile ducts and blood vessels.

The expediency of taking the drug during pregnancy is explained by a change in hormonal levels, which, in turn, can exacerbate a woman's chronic diseases. This can also be caused by changing the location internal organs due to an increase in the size of the fetus.

"No-shpa" in early pregnancy

At the beginning of pregnancy, some women are prescribed the drug in the form of injections. No-shpy injections help relieve uterine tone, which is observed when there is a threat of miscarriage. Therefore, this drug helps to relax the muscles, and this, in turn, is dangerous at a later date, as it can cause premature birth.

Among other pain syndromes, No-shpy injections are used for the following diseases:

• cholecystitis;
• cholangitis;
• gastritis;
• colitis;
• stomach and duodenal ulcer;
• enterocolitis;
• cystitis;
• nephritis;
• pyelitis.

In these diseases, taking the medicine as an anesthetic is possible only after detailed consultation with the doctor. After all, the removal of symptoms can, on the contrary, aggravate the clinical picture of the disease.

"No-shpa" during late pregnancy

Despite the danger of using the drug in the later stages, it is still prescribed in some situations. For example, "No-shpa" during pregnancy before childbirth helps to prepare the birth canal for the passage of a child through them. It has a relaxing effect on the muscles of the uterus, which contributes to its faster opening and facilitating the process.

Some experts believe that the action of "No-shpa" before childbirth helps to reduce the pain of contractions, makes the birth period shorter and prevents the occurrence of gaps. All this facilitates the position of the child and helps him pass through the birth canal less painfully.

"No-shpa" during pregnancy in the 3rd trimester has another use. Usually, closer to the scheduled date of birth, a woman may experience training contractions. To be sure that these sensations are false and not true, it is recommended to take a couple of No-shpy tablets.

After some time, it will be possible to understand the authenticity of the contractions. If they were training, then the pain will subside. But if these are real labor pains, then taking pills will not change the situation.

Tablet form

In the instructions for use for No-shpe, the dosage of tablets is indicated from 80 to 240 mg per day. The optimal dosage is determined by the doctor. Usually prescribed 1-2 tablets three times a day.

In the instructions for use, the dosage of "No-shpy" in tablets varies depending on the pain syndrome that needs to be neutralized. The minimum dosage is 80 mg, so 2 tablets are most often taken (40 mg are available).

injections

Usually, to achieve the effect more quickly, especially in emergency situations, "No-shpu" is used in the form of injections. The instructions for No-shpy injections state that this dosage form is suitable for those patients who have lactose intolerance. It is she who is contained in the tablet form of the drug.

In the instructions for No-shpy injections, the intramuscular dosage of the drug is indicated from 40 to 240 mg per day. Although the dosage of injections does not differ from the dosage of tablets, the effect of the drug administered intramuscularly occurs much faster. This plays an important role in emergency situations, for example, with a threatened miscarriage or with a rapid birth.

Usually, during labor, a single dose of 40 mg of the drug is administered. If necessary, this manipulation is repeated after a few hours. In some patients, the relaxing effect of "No-shpa" contributes to a more rapid opening of the cervix. In addition, the process itself is less painful, which allows you to save energy for the decisive moment.

When the muscles are relaxed under the action of an antispasmodic, the likelihood of tissue and mucous membrane ruptures is much less.

The disadvantage of using "No-shpy" in injections is the formation of painful seals, which are called "infiltrates". They occur at the injection sites, since the drug is administered intramuscularly. However, do not worry, because the infiltrates resolve within a few months.

Time to remove a substance from the body

Like any other drug, "No-shpa" is removed from the body after some time. Absorbed fairly quickly. After about an hour, the concentration of the drug in the blood reaches its maximum.

The active substance "No-shpy" is able to bind to plasma proteins. In addition, the drug is metabolized in the liver. The time for complete elimination of metabolites by the kidneys is 72 hours.

How long does "No-shpa" work? Since the drug is absorbed quickly enough, it begins to act within 10-15 minutes.

Effect on the fetus

"No-shpa" during pregnancy in the 3rd trimester is able to have some effect on the baby, but this drug does more harm to the mother. By the way, in some European countries, this medication is generally prohibited.

Studies have been conducted, during which it was revealed that with prolonged use of the drug in children, developmental delays were observed. The most noticeable negative consequences are speech problems in babies.

The use of "No-shpy" during pregnancy in the 3rd trimester in the reviews of women is indicated as a useful method. Women who used this drug as prescribed by a doctor note that it relieves pain of various etiologies well. However, it should be taken with caution and only after consulting a doctor.

Does "No-shpa" harm?

This drug, like any other, has its own contraindications for use.

• "No-shpa" during late pregnancy can cause premature birth.
• If a woman has problems with the kidneys, heart, liver or pressure (in particular, if it is lowered), then taking the drug is not recommended.
• Allergic reactions to the active substance of the drug or to auxiliary components may occur.

Due to the presence of the contraindications listed above, the dosage of "No-shpa" during pregnancy in the 3rd trimester is set only by a doctor. He also determines the appropriateness of the use of this drug in each case.

In addition to the fact that during the period of bearing a child, this medicine can increase toxicosis, reduce appetite, cause weakness and heart palpitations, in some cases it can cause postpartum hemorrhage. Therefore, the use of "No-shpa" or drotaverine in its pure form during labor is undesirable or should be under the constant supervision of a physician. Due to the ability of the drug to relax the smooth muscles of the organs, the uterus does not contract after childbirth, which causes undesirable postpartum period bleeding.

Studies have shown that the drug does not have an irreversible negative effect on the fetus during pregnancy. However, some European countries do not practice taking the drug during the period of bearing a child - their studies show that in children there is a delay in speech development in the future. Domestic researchers do not provide such data.

Another advantage of the drug is its ability to normalize the child's cardiac activity. Women who were diagnosed with tachycardia in the fetus, this drug was administered in the form of injections. According to ultrasound pathology was neutralized.

side conditions

If a pregnant woman has not previously observed negative consequences in herself after taking No-shpa, then with the onset of pregnancy, everything can change. Therefore, it is important to know what side effects this drug can cause. Among them:

• hypotension (lowering blood pressure);
• rapid heartbeat (tachycardia);
• abnormal heart rhythm (arrhythmia);
• dizziness;
• headache;
• insomnia or drowsiness;
• digestive disorders (nausea, vomiting, constipation, diarrhea);
• skin reactions (itching, rash, irritation);
• angioedema (very rare).

"No-shpa" and "Papaverine": joint use

So, it has already been mentioned above how long the "No-shpa" acts. To enhance its effect, the drug is usually prescribed in conjunction with Papaverine.

Both "No-shpa" and "Papaverine" are quite well-known and effective medicines. They have long been among the first of the list of drugs for pain relief.

"No-shpa" is a myotropic antispasmodic, that is, it affects muscle spasms. By removing them and relaxing the smooth muscles, it thereby removes pain. It acts quite quickly, but still, in some cases, its use is accompanied by the intake of "Papaverine".

Often, pregnant women are prescribed additional medicine in suppositories, since this is the most safe way introductions. In addition, when using rectal suppositories, the absorption of the drug is better and faster. At the same time, "No-shpu" is prescribed in tablets or injections. Undoubtedly the most fast action from an injection.

As for the dosage, it is usually 2 "No-shpy" tablets 3 times a day and one rectal suppository "Papaverine" also up to three times a day. Compatibility of drugs is evaluated only by a doctor. Self-administration can harm both mother and baby. The most common unpleasant consequences are premature birth or, on the contrary, too slow labor activity due to the relaxing effect of antispasmodics on the cervix.

Analogues "No-shpy" during pregnancy

Each woman is individual, and the tolerance of drugs is different for everyone. This may affect the specificity of drug therapy for pain syndrome. Despite the fact that "No-shpa" is a universal drug that suits almost everyone, rare reverse cases are also observed. In such situations, it is necessary to replace the medicine. Suitable for this:

• "Drotaverine".
• "Droverin".
• "Spazmol".
• "Bioshpa".
• Spazmonet.
• "Vero-Drotaverine".
• "Nosh-Bra".

If "No-shpa" is a drug that has been proven over the years and does not pose a danger to a pregnant woman, then the analogues listed above should be taken only after consulting a doctor. Replacement of the drug is not allowed without consulting a specialist, especially if a woman is expecting a baby - in this situation it is very dangerous.

Reception "No-shpy" is not a teratogenic factor during pregnancy. That is why the drug is so common in medical practice. However, if there is an opportunity to relieve pain without taking medication, then it is better to use it.

If a woman has no contraindications for taking this drug, then it can be safely taken after consulting a doctor who will prescribe the necessary dosage. Usually in the first trimester, it is prescribed as part of therapy aimed at maintaining pregnancy. However, it may also be used for the symptomatic elimination of toothache or headache. But the use of the drug, starting from the second trimester of pregnancy, is usually carried out only in a hospital. This is necessary to prevent negative consequences and quickly stop emergency situations.

Compound tablets: 40 mg drotaverine (as hydrochloride), magnesium stearate, povidone, talc, cornstarch, lactose (as monohydrate).

Tablets Forte have the same composition. The only difference is the higher concentration of the active substance (80 mg/tab.).

Compound No-Shpy in ampoules: drotaverine hydrochloride at a concentration of 20 mg / ml, 96% ethanol, sodium metabisulfite, water for injection.

Release form

Forms of drug release:

• No-Shpa tablets, 6 or 24 pcs. in blisters, 1 blister per pack, 60 pieces in polypropylene bottles equipped with a piece dispenser, 1 bottle in a pack;
• tablets No-Shpa Forte No. 20, 10 pcs. in blisters, 2 blisters in a cardboard box;
• No-Shpa injections, No. 25 (5 × 5), 2 ml per ampoule, 5 ampoules each (located in a tray), in cardboard box 5 pallets.

Tablets 40 mg biconvex, round, yellow with an orange or greenish tint. Each tablet is engraved with " spa«.

No-Shpa Forte is a biconvex, oblong-shaped tablet of yellow color with an orange or greenish tinge. On one side there is a fault line, on the other is engraved NOSPA«.

The drug in injection form has the form of a clear yellow-green liquid.

pharmachologic effect

Antispasmodic.

Pharmacodynamics and pharmacokinetics

Drotaverine - This myotropic antispasmodic . The action of the drug is aimed at reducing the tone and motor activity of the smooth muscles of the internal organs. In this case, these effects are accompanied by a moderate expansion of blood vessels.

When taken orally, absorption drotaverine one hundred percent. From the digestive tract, the substance is absorbed very quickly. During the first passage (passage) through the liver, only 65% ​​of the dose enters the bloodstream. TCmax - from 45 minutes to 1 hour.

In tissues drotaverine distributed evenly, penetrates into smooth muscle cells. Does not pass through the BBB. The substance and / or its products can pass through the placental barrier in small concentrations.

T1 / 2 - from 8 to 10 hours. Within 72 hours, the substance is almost completely excreted from the body. More than half of the drug is excreted - mainly in the form - by the kidneys, about a third - through the gastrointestinal tract (excretion into bile). In unchanged form, drotaverine is not detected in the urine.

Indications for use No-Shpa

What do No-Shpy tablets help with?

Indications for the use of No-Shpy:

• spasms of smooth muscles caused by diseases of the biliary tract ( , cholangitis , cholangiolithiasis , cholecystolithiasis , pericholecystitis , papillitis );
• spasms of smooth muscles of the urinary tract , uro- and nephrolithiasis , pyelitis , bladder tenesmus .

As an addition to the main therapy, the drug can be used to relieve spasm of smooth muscles caused by diseases of the stomach and intestines . Indications for use are: , meteoric forms of spastic colitis , as well as SRCT with , spasms of the pylorus and cardia .

In addition, it is advisable to take No-Shpu at and at . No-Shpa for headaches is effective if the cause of the pain is a spasm of the blood vessels (tension headache or tension pain).

Forte tablets are prescribed when it is necessary to provide a longer effect and reduce the frequency of applications.

Why No-Shpa in injectable form?

No-Shpa in ampoules is used mainly in situations where it is impossible to take pills.

The tablets contain lactose. Its content in one tablet of 40 mg is 52 mg, and in one tablet of 80 mg - 104 mg. In this regard, patients with lactose intolerance may experience complaints from the digestive system.

People with glucose/galactose malabsorption syndrome lactase deficiency And galactosemia only No-Shpy injections should be prescribed.

Parenteral administration of the drug is also indicated for pancreatitis : the disease is often accompanied by debilitating vomiting, due to which taking pills does not give the desired effect.

Does No-Shpa help with toothache?

• damage to the enamel or dentin of the tooth;
• inflammation of the tissues surrounding the root of the tooth;
• pulp inflammation.

Smooth muscles do not play a role in the development of pain syndrome, therefore, taking No-Shpa for toothache does not make sense. However, in some cases, pills can still help. If you put a tablet on your tongue, you can feel that the tongue begins to go numb rather quickly at the point of contact with it.

Contraindications

Contraindications for No-Shpu:

• hypersensitivity to drotaverine or any other substance in the composition of the solution / tablets;
• severe forms kidney and liver failure ;
• low cardiac output syndrome;
• lactase deficiency , galactose intolerance, glucose / galactose malabsorption syndrome (for tablets).

With caution, the drug is prescribed to pregnant women, children and persons suffering from arterial hypotension.

Side effects

The drug usually does not have side effects, however, it must be borne in mind that during treatment, the following can sometimes be noted:

• decline;
• increased heart rate;
• headache;
• nausea;
• hypersensitivity reactions.

If the drug is administered intramuscularly or intravenously, local reactions at the injection site are possible.

Instructions for use No-Shpa (Method and dosage)

Tablets No-Shpa: instructions for use

For an adult to alleviate the condition during the day, it is recommended to take from 120 to 240 mg of drotaverine. Thus, the daily dose is from 3 to 6 No-Shpa tablets. It is recommended to divide it into 2-3 doses.

The maximum allowable single dose is 2 tablets of 40 mg, the daily dose is 240 mg.

The standard dose for a child under 12 years old is 80 mg / day. (the dose is divided into 2 doses), for a child over 12 years old - 160 mg / day. (the dose is divided into 2-4 doses).

The recommended duration of admission without consulting a doctor is no more than 2 days. If the condition does not improve within 48 hours, you should consult a doctor to clarify the diagnosis and select the correct treatment regimen.

In situations where No-Shpa is used as an addition to the main therapy, the recommended duration of admission without consulting a doctor is 2-3 days.

Instructions for No-Shpa Forte

Forte tablets are taken in the same way as 40 mg tablets. The daily dose of the drug is 3-6 tablets divided into 2-3 doses.

No-Shpa ampoules: instructions for use

Average daily dose drotaverine in ampoules for an adult - from 40 to 240 mg. The drug is administered intramuscularly for 1-3 separate injections.

No-Shpa IV is administered to patients with stones in the bile or urinary tract at acute colic . A single dose is from 40 to 80 mg (the solution should be administered slowly).

How long does the medicine take to work?

The effectiveness of the drug No-Shpa is three to four times higher than the effectiveness papaverina . In addition, the drug is characterized by 100% bioavailability. When taking a tablet drotaverine very quickly absorbed from the gastrointestinal tract: the half-absorption period of the substance is 12 minutes.

When taken orally, the action of No-Shpa appears after 10-15 minutes, and when administered intramuscularly, within 5 minutes.

Dosage for animals

Dosage for dogs - 40 mg (1 tablet) for every 10 kg of body weight. If the parenteral administration of the drug is indicated for the animal, the dose is 1 ml / kg.

Dosage for cats - 0.1 ml / kg, injections are given 2 times a day.

Overdose

A severe overdose of No-Shpa is accompanied by cardiac arrhythmia and violations of the conduction function of the heart, up to a complete blockade of the legs of the PG (His bundle) and cardiac arrest which can lead to the death of the patient.

The literature indicates that the lethal dose of drotaverine is 1.6-2.4 grams (from 40 to 60 tablets of 40 mg each). Death occurred 2-3 hours after the drug was taken. Wikipedia states that the LD50 of drotaverine is approximately 135 mg/kg.

After taking a large dose drotaverine the victim must be under medical supervision. Treatment is symptomatic, including gastric lavage, induction of vomiting, and maintenance of vital body functions.

Interaction

Like other papaverine-like PDE inhibitors, drotaverine weakens antiparkinsonian action. When these drugs are taken in combination, rigidity may also increase.

In combination with others antispasmodics (including with m-anticholinergics) there is a mutual strengthening of the antispasmodic action.

Much of the taken dose drotaverine is in a state associated with plasma proteins (mainly with β-, γ-globulins and ).

There are no data on the interaction of the substance with agents that significantly bind to plasma proteins, however, it is hypothetically possible that they interact at the level of protein binding (one of the drugs may be displaced from this connection, as a result of which the concentration of the free fraction of the drug will increase in the patient, in which weaker protein binding).

Hypothetically, this is fraught with the occurrence of toxic and / or pharmacodynamic effects of such a drug.

Terms of sale

Tablets 40 and 80 mg - without a prescription. Injection form - prescription.

Storage conditions

Store between 15 and 25°C. Protect tablets from light.

Best before date

Tablets - five years. Solution - three years.

The recipe for No-Shpu in Latin looks like this: Rep.: Tab. Drotaverini hydrochloride 0.04 N.10 D.S. 1-3

special instructions

The tablets contain lactose, which should be remembered when prescribing the drug to people with impaired glucose / galactose absorption syndrome, lactase deficiency and galactosemia.

With the on / in the introduction of the solution, due to the risk of collapse, the patient should be in a supine position.

The drug should be used with caution in patients suffering from arterial hypotension .

The composition of the injection form of No-Shpy includes sodium metabisulfite, which can cause allergic type reactions . In sensitive patients (especially those with a history of or ) are possible bronchospasm and onset of symptoms anaphylactic shock .

Patients with known hypersensitivity to sodium metabisulfite should avoid the use of No-Shpa in injections.

Analogues of No-Shpa

Coincidence in the ATX code of the 4th level:

The most famous Russian analogue of No-Shpa is this. Other generics of the drug: Vero-Drotaverine , Bioshpa , Nosh Bra , Ple-Spa , Spazmonet , Spasmol , Spazoverin , Spakovin .

What's better : Drotaverine or No-Shpa?

The composition of tablets and No-Shpa solution as an active substance includes drotaverine hydrochloride . Based on this, it can be concluded that - this is No-Shpa, in fact.

The only significant difference between the drugs is the price: Drotaverine several times cheaper than its imported counterpart.

No-Shpa for children

According to the annotation, there are no restrictions on the use of the solution for intramuscular and intravenous administration in pediatrics. Tablets of 40 mg are prescribed for children from the age of six. Clinical studies of the safety and efficacy of Forte tablets in children have not been conducted.

Indications for use in pediatric practice

It is advisable to give medicine to children with cystitis And nephrolithiasis , abruptly arising spasms of the duodenum or stomach, gastritis, enteritis, colitis, constipation, spasm of peripheral arteries, high temperature and severe headaches.

Contraindications for children

In children, the use of No-Shpa is contraindicated in heart, kidney or liver failure , individual intolerance to the components of the drug, low blood pressure, impaired absorption of galactose / lactose, angle-closure glaucoma , bronchial asthma , atherosclerosis of the coronary arteries .

The use of tablets is categorically contraindicated in children under 12 months, but it is considered safest to give the drug from the age of six. Very small children are so powerful .

To bring down the temperature, you can use the simple combination "No-Shpa + Analgin «.

The dosage of each drug is calculated depending on the age of the child. So, for example, for a child of 2 years old, ⅓ tablets of Analgin and ⅓ tablets of No-Shpy are enough.

No-Shpa and alcohol

Alcohol and No-Shpa are incompatible. However, the drug can be used to treat a hangover (it is recommended to do this under the supervision of a narcologist).

No-Shpa during pregnancy and breastfeeding

Drotaverine has a relaxing effect on all smooth muscle structures of the body, while provoking the expansion of blood vessels and contributing to an increase in blood flow to various organs.

During the remedy is used mainly for the tone of the uterus in the early stages. It is not prescribed before childbirth, this is due to the fact that taking No-Shpa before childbirth will help to relax and open the cervix.

Taking the drug during childbirth helps to normalize the contractile activity of the muscles of the uterus and reduce pain, reduces the risk of injury, and also reduces the period of labor. Despite this, in many European countries, the appointment of No-Shpa during childbirth is considered a relic of the old school.

No-Shpa is considered safe for pregnant women. Clinical experience with the use of the drug in pregnant women, as well as the results of reproductive studies conducted on animals, show that drotaverine It has neither embryotoxic nor teratogenic effects.

However, during pregnancy, it is necessary to balance the potential benefits for a woman with the possible risks to her unborn child.

Dosage of No-Shpy during pregnancy

For pregnant women, the form of the drug and the daily dose are selected individually. With increased tone of the muscles of the uterus in early pregnancy, the recommended dose varies from 80 to 240 mg / day.

No-Shpa in ampoules is usually used to prepare for childbirth. injections drotaverine accelerate the process of opening the cervix. The drug is injected into the muscle at a dose of 40 mg. After a few hours, the injection is repeated if necessary.

Women who took the drug during pregnancy - reviews are confirmation of this - assure that No-Shpa not only copes well with severe cramps in the first months of pregnancy, but also greatly facilitates the course of childbirth.

No-Shpa while breastfeeding

Due to the fact that the necessary clinical data on the use of No-Shpa with little, it is not recommended to prescribe the drug for HB.

Any drug has contraindications and side effects. Taking medications, people understand that they may encounter some unpleasant phenomena. When drugs are prescribed to pregnant women, it is necessary to take into account the possible harm not only for the patient, but also for the unborn child.

Among all known drugs, there are only a small number of drugs, the use of which is allowed during pregnancy. These medicines include No-Shpu, which is an excellent antispasmodic. The active substance of this drug does not harm the body of the fetus and allows you to relieve spasms, which sometimes pose a threat to a woman who is in position.

No-Shpa: active ingredient, properties

The main substance that ensures the effectiveness of No-Shpa is drotaverine. It affects the smooth fibers of the muscles that form the walls of the internal organs, acting as an antispasmodic.

After taking this medication, the muscle tissues located in the uterus, the walls of the stomach and other organs become relaxed, spasms and pains are eliminated. Additional components of the drug are talc, magnesium stearate and corn starch.

The advantage of No-Shpa over antispasmodics of central action is that it does not affect the peripheral regions. nervous system and does not affect the CNS. This explains the fact that the drug does not have serious side effects. No-Shpa is often used for gynecological pathologies, is used in urology and gastroenterology, and for headaches.

In addition, it is prescribed to women who are carrying a child to relieve uterine spasms in order to maintain pregnancy. The active substance of this medicinal product dilates and relaxes blood vessels, which improves the supply of oxygen to tissues. Experience has shown that No-Shpa is effective in fetal tachycardia. Sometimes her injections are used at the beginning of labor in order to ensure full disclosure of the cervix.

Given that Noshpa acts on smooth muscle structures, it must be remembered that it also affects blood vessels. When the walls of blood vessels relax, the pressure decreases slightly. This effect is mild, but may occur in pregnant women suffering from hypononia, or when taking a large dose of the drug.

No-Shpa and pregnancy: indications for admission in the first, second, third trimester

During the first trimester of pregnancy, a woman carrying a child should pay special attention to her health and lifestyle, since at this time the formation of all systems and organs of the fetus begins. If any deviations in health occur, a woman should immediately consult a doctor.

At the initial stage of pregnancy, No-Shpu is usually recommended when uterine hypertonicity is determined and there is a threat of miscarriage. The active element of the drug causes relaxation of the muscular structures of the uterine wall and maintains its normal tone. Due to these properties, No-Shpu is often prescribed in the first trimester to ensure the normal development of the unborn baby.

During pregnancy in the second and third trimesters, the drug should be drunk with great care. In the late stages of pregnancy, the task of the woman and the doctor is to support the development and growth of the child. Starting at 33 weeks future mom together with the gynecologist, they must ensure the physiological readiness of the baby at the time of birth. For this reason, at 36, 37 and 38 weeks, medications should be avoided, which can adversely affect the condition of a pregnant woman and cause premature birth.

The use of No-Shpa in the last stages of pregnancy after 36 weeks can remove increased tone uterus, but drotaverine also affects the cervix. This can contribute to its early disclosure and induce labor before the due date. Most often, doctors prescribe No-Shpu to patients who are at 39 weeks of gestation.

Contraindications in pregnant women

Before you start taking No-Shpa, you should carefully study the information regarding its appointment during pregnancy. The use of the drug has a number of limitations when it comes to pregnant women.

It is forbidden to take No-Shpu in the following cases:

• earlier than 8 weeks in accordance with the obstetric period;
• high individual sensitivity of the patient to the components in the composition of the drug;
• pathological conditions of the cervix;
• low blood pressure;
• blockage of the coronary arteries;
• glaucoma;
• chronic pathologies of the liver;
• kidney disease.

Instructions for use of tablets and injections

No-Shpa is a myotropic antispasmodic drug that has the greatest effect on the muscle fibers of the reproductive, urinary and digestive systems. The main symptoms in which drotaverine is indicated for use during pregnancy are pain, petrification in the lower abdomen. These phenomena may indicate a threat of miscarriage in the early period of gestation.

No-Shpa is produced in the form of tablets and solution for injection. What form of the substance will be most suitable for each woman, how many times a day to take the medicine, the doctor sets in accordance with the instructions for the drug.

Scheme and dosage

When taking No-Shpa, you should not exceed the maximum dosage, which is 240 mg per day. If one tablet contains 40 mg of the active ingredient, then you can take no more than 6 tablets per day. If in one tablet the concentration of drotaverine corresponds to 80 mg, then a maximum of 3 pieces per day is taken. With a single use, pain and spasms should disappear within 1 hour.

The daily dose must be divided into 3 parts. Thus, at one time you can not use more than 80 mg of the active substance.

There are times when the doctor recommends No-Shpa injections. If the drug is used intramuscularly or intravenously in the form of injections, then the same maximum allowable doses of administration are observed as when taking the tablet form of the substance. Noshpa injections during pregnancy help prevent the threat of miscarriage in the first trimester.

Pregnant women should not drink or inject Noshpa for more than 1-2 days, as with a longer course of treatment there is an increased risk side effects. If spasms, pain and increased tone do not go away after a two-day intake, then further actions must be agreed with the doctor.

drug interaction

When prescribing No-Shpa during pregnancy, it should be borne in mind that drotaverine, which is its active component, can enhance the hypotensive effect of other drugs taken by a woman. For this reason, it should be clarified whether the patient is taking tricyclic antidepressants, procainamide or quinidine.

It is also prohibited to use Noshpa in conjunction with other drugs of the antispasmodic group. The simultaneous use of these drugs can provoke increased relaxation of muscle fibers, which will lead to premature delivery.

Immediately before the onset of labor, Noshpa and Buscopan can be combined. This combination of drugs prevents ruptures during labor.

Side effects and symptoms of overdose

No-Shpa during pregnancy is shown quite often. This is due to its relative safety and a small number of side effects. However, in some cases unwanted effects from the use of the drug are still noted. Against the background of the use of No-Shpa in pregnant women, there may be:

• constipation;
• nausea;
• allergic skin rashes, angioedema;
• headaches and dizziness;
• tachycardia;
• decrease in vascular tone and blood pressure.

If the patient notices one of these symptoms after taking the medicine, then he should consult with his doctor. Perhaps a woman has an individual intolerance to the components of the drug. Then another remedy will be prescribed for her.

An overdose of No-Shpoy occurs in case of non-compliance with the instructions. A person may intentionally or inadvertently drink too much of a substance, as a result of which the following symptoms appear:

• nausea, vomiting;
• intestinal obstruction;
• chest pain;
• loss of consciousness;
• heart rhythm disturbances;
• depression and respiratory arrest.

In case of overdose, the patient should be induced to vomit. Hospitalization and gastric lavage are mandatory.

How does No-Shpa affect the fetus?

Numerous experiments have shown that drotaverine does not have a negative effect on the fetus in the stage of intrauterine development. No-Shpa is considered a completely safe drug, which ensures widespread use in gynecology and use in early pregnancy.

When examining newborns, specialists did not reveal any abnormalities in their development associated with the intake of drotaverine by the mother. Doctors note the greater effectiveness and duration of action of No-Shpa in comparison with other antispasmodics. However, we must not forget that the absence of a negative impact occurs only if the recommendations of doctors are followed.

Some Western doctors suggest that taking drotaverine by a mother during pregnancy may affect the development of her baby after birth. In particular, they associate the lag in the development of speech with the frequent use of the drug by the mother. This hypothesis has no scientific confirmation, but, in any case, a woman carrying a child should adhere to the permissible dosages of the drug, and prolong the course of treatment only on the advice of a doctor.

Drug analogues

No-Shpa has a number of analogues that also relieve spasms and eliminate pain. However, not all of them are indicated during pregnancy. Some drugs are toxic and have a negative effect on the child in the womb, so during pregnancy it is forbidden to take any antispasmodics on your own without consulting a doctor. The analogues of No-Shpa closest in action are shown in the table.

Name	Active ingredient	Application features
Papaverine	papaverine hydrochloride	It is not used for glaucoma, liver pathologies, hypothyroidism, renal failure and supraventricular tachycardia. It is used for spasms of smooth muscle fibers of the abdominal organs, effective for bronchospasm and spasms of cerebral vessels.
Duspatalin	mebeverine hydrochloride	It is prescribed for violations in the work of the gastrointestinal tract, spasms and irritable bowel syndrome. May cause allergic skin symptoms.
Niaspam	mebeverine hydrochloride	Effective in the treatment of spasms of the stomach and intestines. Practically does not cause side effects, in some cases urticaria, angioedema may occur.

No-Shpa, the main element of which is drotaverine, is considered the most effective in relation to the smooth muscle fibers of the uterus. In addition, its safety for the fetus has been proven. The combination of these properties makes the drug indispensable in the treatment of pathological conditions that occur during pregnancy. It is prescribed in most cases when ICI and uterine hypertonicity occur, but depending on the gestational age, the duration of the course and the number of doses are determined individually for each woman.

Among the medications that can be taken by women in position, No-shpa is of particular importance. A powerful antispasmodic that effectively copes with the uncomfortable and painful sensations that occur in mothers against the background of gastrointestinal disorders and other problems. No-shpa during pregnancy 2nd trimester is completely safe, it can be taken without fear for the child. But it is still worth observing certain precautions for pregnant women, because the drug has its own side reactions and contraindications.

Before visiting the pharmacy, consultation with the attending gynecologist is strictly required.

The active drug component is drotaverine - this is a very strong antispasmodic substance with myotropic effects, which means the ability of the agent to act on smooth muscle structures located in the walls of abdominal organs such as the uterine body, stomach, intestines, etc.

• No-shpa during pregnancy helps to relax muscle tissue and eliminate spasms, which helps to cope with pain or significantly reduce it.
• In comparison with muscle relaxants of the central effect, which also eliminate smooth muscle spasms, No-shpa does not depress the nervous system structures, therefore it does not cause adverse reactions such as diaphragmatic paralysis or respiratory depression. Therefore, No-shpa is often prescribed during pregnancy in the 3rd trimester, as the drug of choice for gynecological and obstetric problems.
• The drug can slightly lower blood pressure, so it is recommended to take it with caution during pregnancy at all gestational periods if the mother suffers from hypotension. Just a remedy, having a systemic effect on smooth muscles, affects cardiovascular activity, relaxing peripheral vascular channels.

The effect of pressure reduction is not pronounced, the pressure decreases only with a large dosage, so you should not worry about whether it is possible to drink No-shpu during gestation.

Can pregnant women drink

During the period of gestation, No-shpa is considered the most commonly used medication, but drinking No-shpa during pregnancy is permissible when the therapeutic effect for the patient clearly outweighs the possible risks for the baby. Therefore, for those who doubt whether this medication based on drotaverine can be used by pregnant women, gynecologists report that this remedy is often necessary for pregnant women, especially those at risk of interruption.

The drug has a mild and targeted antispasmodic effect on smooth muscle tissues, helping to safely and without risk for the baby relieve tension and spasms from them. No-shpa in the first trimester is quickly absorbed into the bloodstream, effectively eliminates spastic pain, without causing almost no adverse reactions. This medicine is popular among expectant mothers, but it is still permissible to drink the medicine as prescribed by an obstetrician-gynecologist.

Application at different gestational ages

If you feel unwell, avoid junk food

If the patient passed the first screening and the results showed the presence of a threat of interruption against the background of uterine hypertonicity, then No-shpa is recommended during pregnancy for the 1st trimester. The drug will gently relieve uterine spasms and relax the tense walls of the organ, minimizing the likelihood of spontaneous interruption. Such a therapeutic effect is provided by the influence of drotaverine, which has a powerful antispasmodic effect with a minimum of adverse reactions.

In the first trimester of pregnancy, it is important to avoid uterine hypertonicity, which, without treatment, inevitably leads to miscarriage. If a similar condition nevertheless occurred during pregnancy in the first trimester, the use of No-shpa in the form of injections or tablets is recommended. In a hospital, injections of the drug are usually administered, because in this form absorption into the bloodstream and the onset of the effect are more intense.

It can also be used as an effective pain reliever for painful sensations varying degrees of intensity. In the second trimester of gestation, the tablets effectively relieve pain, especially when the load on the vertebral structures increases, causing pulling pain in the lumbar region. In this way, you can stop the soreness of migraines, backache or toothache. The effect of the drug comes quickly enough, but in the 2nd trimester it is important to strictly observe its daily dosage. Is it possible to No-shpu in the 3rd trimester?

Attention! With fetal growth, the antispasmodic becomes somewhat dangerous for intrauterine development, which is again due to its ability to relax muscle tissue, which is fraught with premature delivery in the third trimester of pregnancy. The drug in the last trimester acts on the cervical muscles, relaxing them. As a result, the cervical canal opens, the processes of moderate delivery activity are launched.

How does the drug affect the fetus

To study the effect of drotaverine on the fetus, it was administered to pregnant female animals. In the course of these studies, it turned out that No-shpa has a teratogenic effect or a toxic effect on the fetal structures. Therefore, the antispasmodic is so actively used in obstetrics and gynecology for the treatment of pregnant patients.

There is also a theory of Western scientists who believe that drotaverine, when taken excessively, can negatively affect fetal structures, slowing down speech development crumbs. Specialized studies in this direction were not carried out, so the assumption remained unproven. But experts still recommend that pregnant women drink No-shpu in accordance with medical prescriptions, strictly observing the dosage and regimen.

In what cases is the drug prescribed

Do not take any medication on your own

In accordance with the attached annotation to the drug, drinking such tablets is indicated for quite a variety of pathological conditions accompanied by spasms of smooth muscle structures. The use of the remedy for pain in the abdomen is especially common, because it is extremely undesirable for pregnant women to take ordinary painkillers and analgesics.

For therapeutic purposes, No-shpa is indicated for pathologies such as renal, hepatic and intestinal colic, biliary dyskinesia and chronic cholecystitis, urolithiasis or cholelithiasis, the threat of spontaneous abortion and uterine hypertonicity. In obstetric and gynecological practice, most often the drug is drunk precisely for the last two reasons.

Uterine tone

It is possible to determine the presence of uterine hypertonicity by the results of the first screening, as well as by the internal sensations of the pregnant woman herself. Such a condition is an obvious threat of interruption of gestation, so the pregnant woman needs to go to the hospital for preservation, where she needs to remain under medical supervision until such a threat disappears completely.

The use of No-shpa in uterine hypertension is mandatory, because it helps relieve muscle spasms and stimulate blood circulation by increasing blood flow. After a course of antispasmodic therapy, the problem is solved, and the patient can safely carry the baby without worrying about his health.

Threat of interruption

In the presence of muscle spasm, pathological narrowing of the vascular channels and impaired blood circulation occur, which leads to a serious increase in the likelihood of interruption in the early stages of gestation.

1. To avoid such a complication, you need to undergo appropriate treatment with drugs prescribed by an obstetrician-gynecologist.
2. Among the prescribed medications, there is also an antispasmodic No-shpa, which relaxes tense muscle tissues and expands the vascular channels.
3. In addition, the tool normalizes vascular patency, and also relieves smooth muscle spasms.

The tool is quite effective and safe for mothers, although it must be taken according to the prescription of specialists and in a strictly limited dosage.

Headache

Well-being affects the quality and duration of sleep

Mothers sometimes suffer from headaches. You need to know exactly the cause of these sensations, only then you can choose the right drug. With severe migraine attacks, a pathological narrowing of the vascular structures occurs, so blood cannot flow to the cerebral membranes in sufficient quantities.

To ease such tension, it is necessary to take an antispasmodic for migraine. As a result, vasodilation occurs, systemic blood flow normalizes, and the attack releases. Ver-Drotaverine, another antispasmodic approved for pregnant women, works on a similar principle.

Bleeding

If a uterine hemorrhage occurs during gestation, complex therapy with medications is prescribed, including No-shpa. When bleeding, it is administered by intramuscular injection or intravenous infusion. This helps to get the fastest effect and stop severe blood loss.

This method of administration helps to increase the viscosity of blood flow and quickly eliminates anxiety. If, however, during bleeding, an antispasmodic is taken in tablet form, then there will be no such pronounced therapeutic effect, therefore No-shpa tablets in this clinical case are ineffective.

For toothache

When carrying out dental treatment, it is problematic to deal with. The main goal of the doctor is to suppress the pain syndrome, since mom cannot endure pain. Experts also recommend using No-shpu, but not inside, but externally. It is necessary to break off ½ of the pill and attach it to the hollow of the diseased tooth, firmly holding it with the jaw.

Practice shows that after about a quarter of an hour the pain will begin to fade away. The analgesic effect with this use of drotaverine is usually present for a couple of hours, then you can take the next dose. The course of treatment of such pain must be agreed with a specialist.

During delivery

Another interesting indication for the use of No-shpa is smooth muscle spasm of the uterine body or cervical canal. This situation is very dangerous, because the baby is squeezed as if in a vise. The tense muscles of the uterus try to push the baby out, but the spasmodic neck prevents this process. Usually, one drop of drotaverine is enough to normalize the delivery process.

Sometimes No-shpa is prescribed before childbirth, when the gynecologist has revealed a high probability of a long, poor opening of the cervical canal due to immaturity. In such a clinical situation, the antispasmodic acts as a medication that prepares the birth canal for the baby to move along them.

No-shpy injections

The most productive antispasmodic effect of the drug is provided when using injections.

• Intramuscular administration of the drug is allowed at home on your own, only you need to discuss this possibility with a specialist.
• This is the safest drug for pregnant women and fetuses with poor blood circulation and arterial spasms.
• The therapeutic effect can be enhanced by combining No-shpu with Papaverine injections. The duration of the course is determined individually.
• Sometimes injections of the drug are administered intravenously when an instant expansion of the vascular channels is necessary.
• Usually, an urgent effect is needed with the threat of interruption, with increasing migraine attacks or uterine hypertonicity.

The drug is perfectly absorbed into the blood and quickly provides the necessary therapeutic effect, then the metabolites leave the pregnant woman's body in natural ways.

Infusion administration of the drug

If the cervical pharynx opens for a very long time, then the doctor often prescribes an infusion of the drug. Such intravenous infusions can accelerate the delivery processes in the last hours before childbirth. Usually, a drotaverine dropper is combined with saline, while no more than two ampoules can be administered per day to a pregnant woman.

As a result of the use of such droppers, the spasm of the pharynx stops and the patient starts labor processes. If the drug causes an allergic reaction, then it can be replaced with infusions with Drotaverine, Papaverine, Spakovin, Spazmonet or Spazoverine.

Dosages

There will be no instant therapeutic effect from taking No-shpa, even if you drink several tablets at once. Therefore, it is unacceptable to violate the dosage recommended by a specialist. Taking the medication during gestation should be carried out strictly normalized, after agreeing it with a specialist. This is necessary, because it is possible to increase the excitability of the myocardium, and the antispasmodic will only be harmful. Therefore, to eliminate painful symptoms, it is necessary to drink only one yellow pill before meals. The therapeutic effect usually occurs after about half an hour, as indicated in the annotation to the drug.

If mommy has a cold or suffers from gastrointestinal pathologies, then it is better to take an antispasmodic by intravenous or intramuscular injections. The therapeutic effect is manifested with this introduction after a quarter of an hour. The decision on the duration of the therapeutic course is made exclusively by the obstetrician-gynecologist, who will definitely take into account possible contraindications to taking the drug and assess the risk of adverse reactions in combination with other medications taken.

Can it be taken without a doctor's prescription?

It is allowed to take No-shpu on your own if the gynecologist has previously recommended that the pregnant patient take this medication. What is the reason for this caution?

1. The pain symptoms that occur during gestation may not always be of spasmodic origin and do not always threaten spontaneous interruption.
2. Sometimes soreness is caused by banal fatigue, emotional experiences or unrest.
3. Rest, yoga, gymnastics, walking before going to bed will help to cope with such pain. Sometimes you need to adjust the diet, excluding dishes that cause epigastric burning and heaviness.
4. In other words, when taking No-shpu, one cannot know for sure how effective the drug will be if you have no idea about the origin of the pain syndrome.

Therefore, when taking an antispasmodic on your own, you need to know exactly the cause of the pain. If this is not known, then it is better not to put the baby at risk, not to take medicine without a medical prescription.

Adverse reactions and overdose

No-shpa, despite the safety for pregnant women, may be accompanied by adverse reactions. The most common side effects are dizziness and increased pulsation, weakness, low blood pressure and constipation, nausea. Also, the remedy can provoke stool disorders and vomiting reactions. Individual intolerance to the drug associated with allergic manifestations such as anaphylaxis and Quincke's edema deserves special attention. If an allergy occurs to lactose in tablets, then the remedy can be taken by injection.

Overdose when taking the drug practically does not occur, since you need to take a lot of pills in order for at least some reaction to occur. In case of an overdose, patients experience a nausea-vomiting reaction and general malaise, intestinal obstruction and constipation. Severe pain may occur behind the sternum, the patient loses consciousness, which is associated with serious violations of myocardial conduction, up to a complete blockade. Respiratory activity is inhibited, up to a stop due to the action of toxins on the respiratory center of the brain.

When is contraindicated

Not all mothers have access to No-shpa treatment during gestation. The drug is contraindicated in case of insufficiency of the kidneys, myocardium and liver, in case of hypersensitivity to the components or galactose intolerance (for tablets). Injections are contraindicated in case of hypersensitivity to sodium disulfide.

Take the medication with caution in the hypotonic form of VVD. With low blood pressure during the injection process, the patient is advised to lie down on the couch to prevent the occurrence of collapse. Hypotension during treatment, it is necessary to control blood pressure.

In general, No-shpa is a harmless drug if you strictly follow medical prescriptions. Side effects are extremely rare. If necessary, the obstetrician-gynecologist will replace the remedy with Spazmol, Drotaverin, Spazoverin, Spazmonet, Spakovin or Nosh-bra, etc.